For example, adenovirus-mediated PRH overexpression in liver cancer cells attenuated hepatocarcinoma growth in a xenograft mouse model.9 A previous study also showed it inhibited migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.10 The PRH S163C:S177C mutated protein was mutated in the PRH homeodomain but retains DNA binding and transcriptional activities. The gene discussed is HHEX; the disease is liver cancer.