Fludarabine, also known as Fludara, is an established specific inhibitor of STAT-129 and is a standard chemotherapy treatment for patients with chronic lymphocytic leukemia.30 Our findings demonstrate that STAT-1 inhibition retards VSMC proliferation and therefore may be responsible, at least in part, for the antiproliferative effects of PRH S163C:S177C. This evidence concerns the gene HHEX and B-cell chronic lymphocytic leukemia.