CD8A and neoplasm: ↓ TGF-β-induced Foxp3 transcription↓ TGF-β-induced Treg generation↓ STAT5 activity → ↓ TGF-β and IL-10 expression in Tregs↓ Rora expression↑ CD8+:Treg ratio within tumors↑ IFN-γ release by CD8+ T cells- intratumor CD8+ T cell proliferation – unchangedLeading to:  ↓ STAT3 activity within tumor cells* curcumin analog GO-Y030 was used