↓ Fas-L, IL-1β, IL-13, TNF-α, CCL11, IGF-II, Leptin, and TIMP-1 in cancer cells↑ IFN-γ, Mig in cancer cells↑ CD4+ and CD8+ lymphocyte and Nk1.1 cell number within tumors in vivo. This evidence concerns the gene CD4 and cancer.