↓Treg and MDSC numbers↑ CD4+ IFN-γ+ T cells → ↑ T cell activation↑ TFN-γ, TNF-α, T-bet mRNAs within tumor↓TGF-β mRNA within tumor- Foxp3 & IL-10 mRNAs within tumor - unchanged. The gene discussed is IFNG; the disease is neoplasm.