↑ Proteosomal degradation of latency-associated nuclear antigen 1 (LANA1)↓ Kaposi’s sarcoma-associated herpesviral replication in infected primary effusion lymphoma cellsLeading to:  ↓ STAT3 activity in lymphoma→ ↓ IL-6 secretion by lymphoma. The gene discussed is STAT3; the disease is primary effusion lymphoma.