EGCG suppressed STAT3 transcription in colorectal cancer cell in vitro to inhibit migration, but promote apoptosis (248) EGCG/67LR promoted apoptosis of multiple myeloma, acute and chronic myeloid leukemias via multiple downstream signaling cascades including p38-MAPK/JNK and JAK2/STAT3 (242–244). The gene discussed is STAT3; the disease is plasma cell myeloma.