↓ IFN-γ-induced expression of PD-L1 in glioma↑ IL-2 and IFN-γ secretion↓ IL-10 secretion↑ proliferation of CD4+ and CD8+ T cells→ reversed glioma-induced inhibition of CD4+ and CD8+ T cells. The gene discussed is CD274; the disease is central nervous system cancer.