↓ STAT3 phosphorylation but ↑ STAT1 phosphorylation in melanoma cells↓ MMP2 expression and activity↓ RORγt, T-bet, GATA3, FOXP3 mRNA↓ IL-10 and IL-6 → ↓ Treg in the TME↑ IFN-γ → ↑ CD8+-mediated cytotoxicity in the TMEPD-L1 levels - unchanged. The gene discussed is CD8A; the disease is melanoma.