Interaction of immune checkpoint molecules like CTLA-4, LAG-3 or PD-1 with their ligands B7.1/B7.2 on antigen-presenting cells, fibrinogen-like protein-1 and Galectin-3 or PD-L1 on tumor cells, respectively, enhance immune escape of tumor cells (41). This evidence concerns the gene LGALS3 and neoplasm.