Notably, the molecular mechanism(s) leading to CD70 upregulation on T cells during chronic systemic inflammation, such as in lupus erythematosus, are governed by epigenetic changes in T cells, such as histone modifications at the TNFSF7 (CD70) promoter (62) with subsequent downregulation of CD27 on terminally differentiated T effector memory RA cells (TEMRA) (63). Here, CD27 is linked to lupus erythematosus.