CD4 and generalized pustular psoriasis: While in generalized pustular psoriasis the association with HLA-DRB1*14, HLA-DQB1*05, and HLA-DQB1*03 as well as strong CD4+ T cell clonality suggested a pathogenic role of CD4+ T cells in the inflammatory infiltrate (94), the CD4+ T cells controlling autoantibody formation may be present in the lymph node, where dendritic cells potentially present self-molecules to T cells.