Interestingly, the HLA-class I alleles HLA-C*06:02, HLA-C*07:01, HLA-C*07:02, HLA-C*07:04, and HLA-B*27 associated with psoriasis are clustered in the same HLA supertype due to overlapping anchor residues in the peptides (51, 55), thus potentially presenting the same psoriasis-specific immunogenic self-peptides. This evidence concerns the gene HLA-B and psoriasis.