These results together indicate that CNDP2 and SERPINH1 play a cancer-promoting effect and may affect the infiltration of immune cells in PC, which could be the underlying factor associated with better prognosis of patients in gene cluster C compared with patients in gene cluster B. Furthermore, in vitro or in vivo experiment would further validate the immunogenic role of CNDP2 and SERPINH1 in the next step. Here, SERPINH1 is linked to pachyonychia congenita.