SERPINH1 and cancer: These results together indicate that CNDP2 and SERPINH1 play a cancer-promoting effect and may affect the infiltration of immune cells in PC, which could be the underlying factor associated with better prognosis of patients in gene cluster C compared with patients in gene cluster B. Furthermore, in vitro or in vivo experiment would further validate the immunogenic role of CNDP2 and SERPINH1 in the next step.