Walter, Simanovich (42) designed a novel epitope-specific antibody against EMMPRIN that inhibits the secretion of MMP-9 and VEGF, shifting the tumor microenvironment of macrophages from an anti-inflammatory microenvironment dominated by TGF-β to one that is less immunosuppressive, thus allowing stimulated macrophages to perform antibody-dependent cytotoxic effects (ADCC) and kill tumor cells. The gene discussed is TGFB1; the disease is neoplasm.