To investigate our hypothesis, we used a mouse model of NSCLC, in which immunocompetent wild type (WT) and CB1-knockout (CB1-/-) or CB2-knockout (CB2-/-) mice received a subcutaneous (s.c.)injection of syngeneic lung adenocarcinoma cells (KP cells (27)), thus creating a tumor model with TME cells that either express or lack CB receptor. The gene discussed is CNR1; the disease is non-small cell lung carcinoma.