PSME2 and cancer: In this study, we first demonstrated the relationship among PSMB8, PSMB9, PSMB10, PSME1, PSME2, and IRF1 in the immune micro-environment and immune score through TCGA whole cancer cohorts, and further, we proved the correlation between PSMB8, PSMB9, PSMB10, PSME1, PSME2, IRF1, and immune cells.