CY administration every 6 days in a syngeneic C57BL/6 mouse glioma model demonstrated that CY modulates a variety of immune-mediated pathways similar to what we observed in our xGvHD model including, cell adhesion/focal adhesion, chemokine signaling, cytokine-cytokine interactions, and JAK/STAT signaling, and was also shown to down regulate steroid biosynthesis, cell cycle, and DNA replication (52). This evidence concerns the gene SOAT1 and glioma.