SPI1 and rheumatoid arthritis: GO analysis of the TFs identified in RA highlighted processes such as response to oxidative stress, cellular response to peptide, negative regulation of protein phosphorylation, etc. GO analysis highlights key immune processes associated with RA pathophysiology regulated by key TFs such as SPI1, RARA, PPARG, NFKB1, ETS1 and MAF (Supplementary Fig. S3; Giaginis et al., 2009; Ikuta et al., 2012; Kang et al., 2017; Manuel Sánchez-Maldonado et al., 2020; Zisakis et al., 2007).