The determination coefficient R2 of the independent variables of each model and its interpretation contribution rate in the model were calculated (Supplementary Table S7), we found that in the models corresponding to IL-6, TNF-α, FIB, CD62P, ICAM-1, ET-1, MMP-9, CHO, TG and AIP, the contribution rate of “effective drug” to the interpretation of the model was greater than that of PM2.5 exposure, and the contribution rate of “effective drug” to the interpretation of IL-6, TG and AIP models was more than 58%. The gene discussed is EDN1; the disease is autoimmune pancreatitis.