Bainbridge-Ropers syndrome (BRPS) or additional sex combs-like 3 (ASXL3)-related disorder is a neurodevelopmental disorder caused by a de novo truncating or missense mutation in the ASXL3 gene found on chromosome 18q12.1 [1-4]. Here, ASXL3 is linked to Severe feeding difficulties - failure to thrive - microcephaly due to ASXL3 deficiency.