STAT3 and rheumatoid arthritis: In RA patient lymphocytes, enhanced nuclear STAT3 activity was observed and inhibition of STAT3 tyrosine phosphorylation or overexpression of the mitoSTAT3 interaction partner GRIM-19 ameliorated RA as it reduced excess glycolytic activity, increased OxPhos activity and reduced the amount of osteoclast stimulating Th17 T cells (Moon et al., 2014; McGarry et al., 2018).