Again, PB from post-treatment RA patients, who are in disease remission phase, showed decreased levels of OPA1. This observation suggests that the heightened expression of GNAQ and OPA1 at the disease site might augment mitochondrial function which plausibly facilitates the enhancement of osteoclastogenesis in the inflamed joints of RA patients. The gene discussed is GNAQ; the disease is rheumatoid arthritis.