EDEM2 and melanoma: We also compared our results with a previous dataset in which one of the key-mannosidases involved in misfolded glycoprotein recognition (EDEM2) was downregulated using siRNA targeting the endogenous EDEM2 and validated our previous EDEM2 candidate-substrates such as ITGA1, PCDH2, HLA-B or tyrosinase, emphasizing the merits of our approach in the identification of bona fide endogenous candidate substrates from melanoma cells.