In accordance with in silico data, Du Y et al. showed a CXCL12 reduction in BlCa patient tissues comparing with the normal tissues Du et al. (2021c), while Yang DL et al. showed a significantly higher expression of CXCR4/CXCL12 in BlCa tissues and no expression in normal tissues Yang et al. (2015). The gene discussed is CXCL12; the disease is bladder transitional cell carcinoma.