Miyake M et al. demonstrated, in vivo and in vitro, that CXCL1 had an important impact in BlCa tumor growth, since promoted IL-6 induction and repressed tissue inhibitor of metalloproteinase 4 (TIMP4) inhibition Miyake et al. (2019). The gene discussed is CXCL1; the disease is bladder transitional cell carcinoma.