CDC42 and macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome: Many de novo mutations within the CDC42 gene result in heterogeneous phenotypes with highly variable symptoms including facial dysmorphism, dysregulation of growth, haematological as well as immunological and neurodevelopmental abnormalities such as Takenouchi-Kosaki syndrome (TKS) (Martinelli et al., 2018; Su and Orange, 2020).