Hypophosphatasia (HPP), a rare genetic metabolic disorder, mainly affects skeletal and dental mineralization due to loss‐of‐function mutation(s) in the ALPL gene that encodes tissue‐nonspecific alkaline phosphatase (TNAP).(1, 2) The adult form of HPP usually presents during middle age. The gene discussed is ALPL; the disease is hypophosphatasia.