SOST and HIV infectious disease: Sclerostin (Scl), the product of the Sost gene, is a potent antagonist of the bone anabolic Wnt/ß‐catenin signaling pathway.(29) Chronic alcohol feeding represses mediators of this pathway in bone,(50) and HIV infection has been linked to Wnt/ß‐catenin signaling inhibition in primary human osteoblasts other tissues.(60, 61) We hypothesized that Scl would positively correlate with alcohol use and negatively with biomarkers of bone formation.