Dickkopf‐1 (DKK1) is another Wnt antagonist secreted by osteocytes, although it is not specific to these cells.(70) DKK1 has been involved in the pathogenesis of multiple myeloma, femoral head necrosis, and obesity.(66, 71, 72, 73) Unlike Scl, it tends to be negatively associated with BMD.(66) Because alcohol use is associated with both inhibition of Wnt/ß‐catenin signaling(50) and osteocyte apoptosis,(74, 75) we measured their circulating levels to assess potential alcohol‐dependent fluctuations. The gene discussed is DKK1; the disease is obesity due to melanocortin 4 receptor deficiency.