However, the histopathological heterogeneities of both morphological and cellular elements in LEAT entities always confuse neuropathologists, and thus the diagnosis of a specific neoplasm needs to combine the histomorphological features with the specific molecular genetic markers in each tumor, such as BRAFV600E, FGFR1, MYB, and PRKCA alterations. The gene discussed is FGFR1; the disease is neoplasm.