IDH2 and neoplasm: Particularly, according to the 2021 WHO classification of central nervous system (CNS) tumors, the DLGG have been divided into adult and pediatric types (Louis et al., 2021), and the adult-type DLGG (Astrocytoma, IDH-mutant; Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted) are recognized as truly invasive neoplasms with a higher risk of tumor progression and malignant transformation (Duffau and Taillandier, 2015; Jones et al., 2018; Lombardi et al., 2020).