Although the GG, DNET, AG, PGNT, MVNT, and PA are deemed the typical tumor entities in the LEAT spectrum, other new tumor entities, especially in the 2021 WHO edition of CNS tumors, are gradually being recognized with close association with LEATs, such as PLGTY and IDG (or pediatric-type diffuse astrocytoma with MYB/MYBL1 alteration), which, however, should be further identified in large cohorts. Here, MYBL1 is linked to central nervous system neoplasm.