Interestingly, 77% of IDGs demonstrated MYM/MYBL1 alterations, and all (100%) were IDH-wild-type, which are closely related to pediatric MYB/MYBL1-altered diffuse astrocytomas, according to the WHO fifth edition of CNS tumor classification (Wefers et al., 2020; Louis et al., 2021). Here, MYBL1 is linked to central nervous system neoplasm.