HTT and Huntington disease: Furthermore, a chronic administration of curcumin in preclinical models of Huntington's disease has been shown to alleviate both the brain pathophysiology associated with reduced levels of huntingtin protein aggregates and to alleviate the motor symptoms described in R6/2 mice, along with reduced inflammation and intestinal damage associated with the progression of Huntington's disease (Elifani et al., 2019).