Consistent with our results, other PSMC signature-related genes, including LDHA (Wu et al., 2020), SEC61G (Zheng et al., 2021), PLEK2 (Wu et al., 2020), and C1QTNF6 (Zhang & Feng, 2021), have been shown to be risk genes in lung cancer in vitro, mediating the development, growth, and metastasis of lung cancer. This evidence concerns the gene PLEK2 and lung cancer.