WASF1 and cancer: WASF1, also known as WAVE1, was a member of the Wiskott-Aldrich syndrome protein family and acted as a regulator between Rac-GTPase and actin to induce actin polymerization (Ito et al., 2018), was an integral part of cell motility and a key step in cancer metastasis (Fernando et al., 2008), which was a hallmark of poor prognosis in patients with LUAD (Inamura and Ishikawa, 2010).