From the distribution of TMB and immune cells infiltration between high- and low-risk groups, patients from the intersection of low-risk and high-TMB groups might produce more effective tumor-associated neoantigens, which could be identified by cytotoxic T lymphocyte and led to more CD8+T cells infiltration, while patients from the intersection of high-risk and low-TMB groups might not produce enough tumor-associated neoantigens, which finally resulted in lower CD8+T cells infiltration. Here, CD8A is linked to neoplasm.