The research used chromatin immunoprecipitation (ChIP) to analyze the binding relationship between estrogen receptor (ER) and SVEP1 promoter and proposed that estrogen treatment would affect the binding of ER and SVEP1 promoter, thereby regulating the mRNA and protein expression level of SVEP1 in breast cancer cells (Shur et al., 2007). Here, ESR1 is linked to breast carcinoma.