RGS5 and neoplasm: In fact, as early as 2008, Hamzah et al. pointed out that inhibiting the expression of G protein signal regulator 5 (Rgs5) can promote the normalization of tumor blood vessels, thereby significantly reducing tumor hypoxia and vascular leakage, facilitating the flow of immune effector cells into the tumor substance, and significantly prolonging the survival time of tumor-bearing mice (Hamzah et al., 2008).