SP1 and neoplasm: Plicamycin, also known as mithramycin A, is a natural polycyclic aromatic polyketide compound that inhibits SP1 transcription factor binding to DNA, which interferes with biological processes like tumour cell proliferation, apoptosis, angiogenesis, invasion, and metastasis (Beishline and Azizkhan-Clifford, 2015; Schweer et al., 2021).