IRF5 and neoplasm: We adjusted these results based on tumor purity, and revealed significant correlations between NR1H3 expression and monocyte markers (CD86, CD115/CSF1R, CD14), macrophage markers (CCL2, CD68, IL10, CD80), M2 macrophage markers (CD163, VSIG4, MS4A4A) and M1 macrophage markers (IRF5), whereas the M1 macrophage markers INOS/NOS2 and COX2/PTGS2 showed no correlation with NR1H3 expression (Supplementary Figure S6A).