The percentage of genetic alterations in PTPN family members for leukemia varied from .6% to 9% for individual genes based on the TCGA, Firehose Legacy dataset (PTPN1, 6%; PTPN2, 5%; PTPN3, 1.2%; PTPN4, 3%; PTPN5, 4%; PTPN6, 5%; PTPN7, 3%; PTPN9, 3%; PTPN11, 9%; PTPN12, 6%; PTPN13, 4%; PTPN14, 6%; PTPN18, 5%; PTPN20, .6%; PTPN21, 5%; PTPN22, 4%; PTPN23, 1.8%; Figure 6A). This evidence concerns the gene PTPN21 and leukemia.