The upregulated genes include: 1) Genes related to leukemia (such as HHEX, NET1), tumor-promoting factors (such as CDK6, HOX family genes), tyrosine kinase genes (c-KIT, GRB10); 2) Prognosis-related genes (such as WT1, CXXC5, MSI2, etc.); 3) CD34 (a marker of hematopoietic progenitor cells); 4) AML drug resistance-related genes (such as IGFBP2 and ABCC1). The gene discussed is IGFBP2; the disease is neoplasm.