Downregulated genes include: 1) Immune system activators, such as CD86; 2) blood tumor suppressors ID2 and KLF4; 3) CEBPB, CEBPB is a BCR/ABL negative regulator gene, which can inhibit the proliferation of BCR/ABL-positive cells, and promote cell differentiation. This evidence concerns the gene CEBPB and neoplasm.