Recent studies that have reported an association of TRPV6 mutations with chronic pancreatitis in multinational, multiethnic cohorts strengthen a causative link between mutant TRPV6 and pancreatitis (Masamune et al., 2020; Zou et al., 2020; Oracz et al., 2021; Hamada et al., 2022). This evidence concerns the gene TRPV6 and chronic pancreatitis.