It is most mentioned that SERPINA5 plays a role in hemostasis, male fertility, and cancer protection (Carroll et al., 1997; Elisen et al., 1998; Uhrin et al., 2000; Bijsmans et al., 2011; Lee E. K. et al., 2013; Jing et al., 2014). This evidence concerns the gene SERPINA5 and cancer.