OTUB2 and depressive symptom measurement: Eight genes were finally left: EGLN3, FNDC3A, MAP3K9, NFATC4, OTUB2, SERPINA5, SUPT16H, and TMEM179. Also, all eight genes were found as at least one target of miRNAs which were reported to be associated with depression/anxiety and microbiota (Figure 7).