In our HNSCC case study, ImaGene further detected strong associations between the expression of eight genes (i.e. NR0B1, PLA2G2A, MAL, CLDN16, PRDM14, VRTN, LRRN1 and MECOM) and imaging attributes such as tumor texture, shape, size and wavelet features (Supplementary Report LR CorrF HNSCC1, Supplementary Report DT CorrF HNSCC2, Supplementary Report LR FS HNSCC3, Supplementary Report DT FS HNSCC4, Supplementary Report MTL FS HNSCC5, Supplementary Report MTEN FS HNSCC6, and Table 3). The gene discussed is CLDN16; the disease is head and neck squamous cell carcinoma.