CD4 and trichinosis: For example, the Trichinella spiralis ES product thioredoxin peroxidase-2 induces macrophages toward an M2-like phenotype, both in vivo and in vitro, and CD4+T cells increased in number after immunization of mice with rTsTPX2 and mediate the expulsion of the worm from the host to protect them, thus suggesting TsTPX2 is a potential vaccine candidate against trichinosis (33).