Schistosome parasite miRNA mediates the activity of the frizzled protein (frizzled-related protein 1), which increases liver fibrosis, in that FRZB2 is a secreted frizzled protein-related protein, which can competitively bind to specific frizzled protein receptors to suppress the signal transduction of Wnt, thus affecting the severity of liver fibrosis. This evidence concerns the gene SFRP4 and Hepatic fibrosis.