TNF and Alzheimer disease: Among highly upregulated genes, we identified IL1β, previously shown to be upregulated in the serum of adult patients with AD (Thijs et al., 2018); TNF, a proinflammatory cytokine whose role in the pathogenesis of AD is well-known (Jacobi et al., 2005; Sumimoto et al., 1992); and early growth response genes EGR2 and EGR3, known to have a crucial role in the regulation of the immune system (Li et al., 2012).