The selected pathways significantly enriched in the AD group included hematopoietic cell lineage, NK cell‒mediated cytotoxicity, phosphoinositide 3-kinase‒protein kinase B signaling pathway, cytokine‒cytokine receptor interaction, extracellular matrix‒receptor interaction, and immunoregulatory interactions between a lymphoid and a nonlymphoid cell (Figure 4a and b). Here, IL18R1 is linked to Alzheimer disease.