NLRP3 and Alzheimer disease: In AD, small Aβ oligomers and protofibrils directly interact with NLRP3 and promote NLRP3 and ASC interaction in a cell free system (Nakanishi et al., 2020) and induce NLRP3 inflammasome activation in primary microglia (Lučiūnaitė et al., 2020).