MyD88 deficiency consistently enhances Aβ peptide phagocytosis by microglia/macrophages and inflammatory activation in vitro, microglial replenishment with MyD88 deficient bone marrow cells, improves cognitive functions by enhancing Aβ phagocytosis, and reduces inflammatory activation in AD mouse models—including APP/PS1 and TgCRND8 mice (Hao et al., 2011). Here, PSEN1 is linked to Alzheimer disease.