Our analysis of the FAERS database suggests that a series of diuretics, antihypertensive drugs with central action, α blockers, β blockers, α and β blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, renin inhibitors, vasodilators and compound preparations may be associated with increased risk of hyperuricaemia, gout or related AEs. The gene discussed is REN; the disease is hyperuricemia.