For example, for hyperuricaemia, a cross-sectional study in Japan showed that uses of diuretics, β blockers and α blockers were associated with increased risk of hyperuricaemia, while uses of calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, including losartan were not associated with risk of hyperuricaemia (Ueno et al., 2016). Here, ACE is linked to hyperuricemia.