In addition, total flavones from Cuscutae Semen (60, 120, and 180 mg·kg-1·day-1) can increase BMD and improve symptoms of osteoporosis by increasing the levels of β-catenin and OPG in OVX rats, reducing the levels of RANKL and DKK1, and regulating the Wnt/β-catenin signaling pathway (Zhao et al., 2018). This evidence concerns the gene TNFRSF11B and osteoporosis.