Combined with the results of network pharmacology analysis and previous studies, it is speculated that Scutellaria barbata may block the PI3K-Akt signaling pathway by active components such as wogonin, hispidulin and eriodictyol etc to inhibit the proliferation and migration of cancer cells, induce apoptosis of cancer cells, and play a role in the treatment of hepatocellular carcinoma. Here, AKT1 is linked to cancer.