Combined with the results of network pharmacology analysis and previous studies, it is speculated that Scutellaria barbata may block the PI3K-Akt signaling pathway by active ingredients such as wogonin, hispidulin and hriodictyol etc to inhibit the proliferation and migration of cancer cells, induce apoptosis of cancer cells, and play a role in the treatment of hepatocellular carcinoma. The gene discussed is AKT1; the disease is hepatocellular carcinoma.