NBR1 may have a role in the development of cytoplasmic inclusions in synucleinopathies because it has been found to localize in Lewy bodies (LBs) in PD and DLB as well as glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA) In addition, NBR1 has attracted interest because of its location close to BRCA1 in the genome. This evidence concerns the gene NBR1 and multiple system atrophy.