APOE and Alzheimer disease: Accumulation of mutant APP (mAPP) and Aβ could lead to neuronal dysfunction (Reddy et al., 2018), and mitophagy enhancers resist effectively mAPP and Aβ-induced mitochondrial and synaptic toxicities in AD (Kshirsagar et al., 2022).Apolipoprotein E (APOE) and APOC1 work together to engage in a number of biological processes, including cholesterol metabolism, membrane remodeling, neuronal death, and neuron reconfiguration (Leduc et al., 2010).