In addition to the above advancements, some bioactive phytochemicals indicate that regulating the activities of GK and HK to increase ERα gene expression and inhibiting the IRE1α-XBP1 pathway to downregulate Ar, Cyp11α1 and Cyp19α1 gene expression are beneficial to the improvement of PCOS. The gene discussed is CYP19A1; the disease is polycystic ovary syndrome.