Rencber et al. further disclosed that RVT could not only reduce the level of these factors by activating the AMPK-SIRT-1 pathway but also downregulate the levels of anti-Müllerian hormone (AMH), T, LH, and LH/FSH, giving rise to ameliorate the hormone disorders of PCOS and the structure of follicular cells (Rencber et al., 2018). This evidence concerns the gene BRD2 and polycystic ovary syndrome.