Khorchani et al. reported that low expression of the Nesfatin-1 and AdipoR1 genes was associated with obesity, and treatment with quercetin increased the expression of the Nesfatin-1 and AdipoR1 genes, showing a good effect on weight loss and other symptoms caused by obesity (Khorchani et al., 2020). This evidence concerns the gene NUCB2 and obesity due to melanocortin 4 receptor deficiency.