IL1B and polycystic ovary syndrome: Farkhad et al. found that treatment with soy isoflavones could reduce the total oxidative state (TOS) and inflammatory cytokines IL-6, IL-12, IL-1β, and TNF-α in estradiol valerate (EV)-induced PCOS rats and increase the total antioxidant capacity (TAC) (Farkhad and Khazali, 2019).