Moshfegh et al. utilized saffron petal anthocyanins (SPA) to treat testosterone-induced PCOS mice and disclosed that SPA could improve the hormone disorder, which was evidenced by the recovery of serum levels of LH, FSH, and steroid hormones (estrogen, progesterone, and testosterone) in mice (Moshfegh et al., 2022). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.