In addition to the above advancements, some bioactive phytochemicals indicate that regulating the activities of GK and HK to increase ERα gene expression and inhibiting the IRE1α-XBP1 pathway to downregulate Ar, Cyp11α1 and Cyp19α1 gene expression are beneficial to the improvement of PCOS. This evidence concerns the gene CYP11A1 and polycystic ovary syndrome.