HSD3B2 and polycystic ovary syndrome: In NCI-H295R cells and the DHEA-induced PCOS rat model, Yu et al. discovered that baicalin could improve the hyperandrogenism of PCOS by destroying the binding of the HSD3B2 gene to the promoter GATA1 and reducing the expression of ovarian HSD3B2, resulting in reduced testosterone secretion (Yu et al., 2019).