In addition to the above advancements, some bioactive phytochemicals indicate that regulating the activities of GK and HK to increase ERα gene expression and inhibiting the IRE1α-XBP1 pathway to downregulate Ar, Cyp11α1 and Cyp19α1 gene expression are beneficial to the improvement of PCOS. Here, ERN1 is linked to polycystic ovary syndrome.