PFK2, also known as 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB), has four isoforms, of which PFKFB3 is a downstream target of HIF-1α that is significantly elevated in PC and correlates with poor clinical prognosis (Shi et al., 2017; Wang F. et al., 2020). The gene discussed is PFKFB3; the disease is pachyonychia congenita.