Recently, it was found that PFKFB2 is also overexpressed in pancreatic cancer, and mRNA spliceosomes of different PFKFB2 are localized in the cytoplasm and nucleus, respectively, affecting F-2,6-BP levels, glycolytic activity, and cell proliferation (Ozcan et al., 2020). This evidence concerns the gene PFKFB2 and familial pancreatic carcinoma.