By observing the effect of Shugan Jianpi Qingre recipe on the expression of 5-hydroxytryptamine1A (5-HT1A) receptor and cyclic phosphatidylinosine effector binding protein (CREB) in the gastric mucosal tissue of FD model rats, we found that it could reduce the expression of 5-HT1A receptor content, increase CREB expression in gastric mucosa, regulate visceral sensitivity, and improve body mass and symptoms in FD rats (Lang et al., 2020). This evidence concerns the gene HTR1A and Fabry disease.