EIF2AK3 and Fabry disease: By observing the expression of PERK protein in the PixuIFormula, FD rats and the treatment of FD with Spleen Deficiency Formula 1, Lv showed that the expression of PERK protein was elevated in model FD rats compared with the normal group, and after the drug intervention with Spleen Deficiency Formula 1, the expression of each PERK protein was reduced compared with the model group, which could improve the cellular UPR phenomenon (Lv et al., 2017).