CRHR1 and Fabry disease: By observing the distribution and expression of peripheral duodenal CRF and CRF-R1 in the central nervous system of FD rats, Zhu found that CRF expression was up-regulated in FD rats and that Jianpiliqi Fang could inhibit CRF expression levels and participate in brain-gut interaction, thus treating FD (Zhu et al., 2020).