GNRH1 and endocrine system disorder: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder in reproductive-age women which is characterized by the accretion of small cystic follicles in the ovary, increased GnRH pulsatility, hypersecretion of luteinizing hormone (LH), anovulation, hyperandrogenemia, and insulin resistance (1–3).