The role of TREM-1 in mounting a dysregulated and deleterious inflammation has been proven in acute diseases or syndromes such as septic shock (9), myocardial infarction (10), or stroke (11), but also in chronic disorders: inflammatory bowel diseases, atherosclerosis, arthritis, lupus, and cancer (12–16). The gene discussed is TREM1; the disease is myocardial infarction.