Although the precise mechanisms by which TREM-1 inhibition confers protection remain to be elucidated, we hypothesized that the reduction of the HFD-induced inflammation may be the primum movens preventing the development of insulin resistance and thus breaking the vicious circle (HFD induces inflammation that leads to insulin resistance that alters energy use and fat deposition and perpetuates inflammation). This evidence concerns the gene TREM1 and Insulin resistance.