TREM1 and hypertensive disorder: showed that serum concentrations of the soluble form of TREM-1 (sTREM-1), which is known to be a marker of the TREM-1 pathway activation (17), were elevated in non-obese young healthy adults with cardiometabolic risk factors (abdominal obesity, fasting hyperglycemia, hypertriglyceridemia, high blood pressure) (18).