Moreover, compared to benign tumors, miR-101 expression is higher in SDHD-mutant malignant PCC tissues (155), and miR-375 is emerging as a new epigenetic alteration that is involved in neuroendocrine tumorigenesis because its overexpression in MTC has been demonstrated both by Hudson et al., and Manso et al. The gene discussed is SDHD; the disease is adrenal gland pheochromocytoma.