HIF1A and adrenal gland pheochromocytoma: Pathway enrichment analysis from exosome sequencing of MCT has identified enriched pathways, including the hypoxia-inducible factor-1 (HIF-1) signaling pathway (hsa04066; 1.3%), and some of the germline mutations were involved in stemness regulation, the first hit of which may drive adrenocortical adenoma (ACA) and PCC formation.