Consistently, amoeboid cells support tumour-initiating abilities in melanoma, where ALDH1 is a strong biomarker of self-renewal (Rodriguez-Hernandez et al., 2020) and podoplaninhigh amoeboid melanoma cells are linked to a clear de-differentiation state (de Winde et al., 2021). The gene discussed is ALDH1A1; the disease is melanoma.