STAT3 and cancer: STAT3 (Yu et al., 2009; Kaplan, 2013) and NF-κB (Liu et al., 2017) act as central transcriptional hubs controlling inflammatory secretion in immune responses, and drive cancer progression and amoeboid dissemination (Pan et al., 2018; Taniguchi and Karin, 2018; Owen et al., 2019).