Comparatively, Rho-ROCK signalling sustains cancer amoeboid behaviour through cytokine secretion-driven positive feedback via IL-6 family cytokines/GP130-JAK1-STAT3 (Sanz-Moreno et al., 2011), TGF-β-SMAD2-CITED1 (Cantelli et al., 2015) and IL-1α-NF-κB (Georgouli et al., 2019). The gene discussed is RHO; the disease is cancer.