In tumours, the shift between elongated-mesenchymal and rounded-amoeboid migration modes are in part governed by the balance of Rho and Rac signalling (Sahai and Marshall, 2003; Sanz-Moreno et al., 2008), cytokine signalling (Sanz-Moreno et al., 2011; Cantelli et al., 2015; Georgouli et al., 2019) and mechanical sensing (Liu et al., 2015). Here, AKT1 is linked to neoplasm.