TTN and myotonic dystrophy type 1: Missplicing of a set of muscle-specific genes including TTN (titin), DMD (dystrophin) (Yamashita et al., 2012), CLCN1 (chloride voltage-gated channel 1) (Charlet et al., 2002; Mankodi et al., 2002), and RYR1 (ryanodine receptor 1) (Kimura et al., 2005), among others, can be directly linked to specific DM1 symptoms.