Missplicing of a set of muscle-specific genes including TTN (titin), DMD (dystrophin) (Yamashita et al., 2012), CLCN1 (chloride voltage-gated channel 1) (Charlet et al., 2002; Mankodi et al., 2002), and RYR1 (ryanodine receptor 1) (Kimura et al., 2005), among others, can be directly linked to specific DM1 symptoms. Here, RYR1 is linked to myotonic dystrophy type 1.