GJB2 and KID syndrome: Furthermore, the F1 progeny obtained from crossing a female Cx26+/floxS17F with a male CMV-Cre mouse (ubiquitous Cre recombinase activity) expressed Cx26S17F instead of Cx26 (KI Cx26S17F) exhibit skin damage, resulting in a suitable model for KID syndrome (Supplementary Figure S1).