Reduced dopamine transporter (DAT)‐binding was seen in the majority of the 39 GNDs with available dopaminergic imaging results, but not in Rett syndrome, Dravet syndrome (SCN1A), dihydropteridine reductase deficiency, and CLTC. This evidence concerns the gene SLC6A3 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.