Pathogenic, exonic variants have been identified in the PLB gene associated with DCM; to date, there are six known PLN mutations linked to dilated cardiomyopathy (p.R9C, R9L, R9H, R14del, R25C, L39X) (9–11) with several more candidate mutations suggested from large scale surveys [e.g., (12)]. The gene discussed is PLN; the disease is familial dilated cardiomyopathy.