Despite the need for mechanistic validation study in larger animal models, AT1R blockers, such as Losartan and Telmisartan (69, 72), were shown to slow AAA growth and rupture in elastase-treated brown rats and hypertensive BPH/2 mice even though conflicting result was observed from a randomized clinical trial in patients with AAA (73). The gene discussed is AGTR1; the disease is triple-A syndrome.