SRPX2 and Leigh syndrome: In patients with LSS, their genetic profile significantly correlated with the upregulation of Laminin subunit alpha-4 (LAMA4) and Sushi-repeat containing protein x-linked-2 (SRPX2) gene that provoked ECM degradation and the downregulation of several pro-inflammatory chemokines that suppress inflammation, suggesting that shear stress dynamics are capable of directly modulating ECM degradation programs through distinct transduction pathways during the progression of AAA.