We have adjusted regarding demographics (BMI), comorbidities (diabetes mellitus, coronary artery disease, atrial fibrillation, EF, hyperlipidemia, hyperuricemia, stroke, COPD, non-invasive ventilation and infection), laboratory parameters (hemoglobin, albumin, eGFR, BUN, sodium, potassium, baseline NT-proBNP), and medications (spironolactone, hydrochlorothiazide, ARB/ACEI, statin, digoxin) for multivariate analysis of 7-day mortality (Figure 2). The gene discussed is NPPB; the disease is hyperlipidemia.