2021 ESC guidelines for the diagnosis and treatment of HF indicated that ACEIs/ARNIs, β-blockers, mineralocorticoid receptor antagonists (MRAs), sodium-glucose cotransporter 2 (SGLT2) inhibitors (dapagliflozin/empagliflozin) and loop diuretics are the cornerstone treatment for HF (23). The gene discussed is NR3C2; the disease is hydrops fetalis.