We have adjusted regarding demographics (age, BMI), comorbidities (diabetes mellitus, coronary artery disease, atrial fibrillation, EF, hyperlipidemia, hyperuricemia, stroke, COPD, non-invasive ventilation and infection), laboratory parameters (hemoglobin, eGFR, sodium, potassium, baseline NT-proBNP), and medications (hydrochlorothiazide, ARB/ACEI, β-Blockers, statin, digoxin) for the multivariate analysis of 90-day mortality (Figure 3). The gene discussed is NPPB; the disease is diabetes mellitus.